Research Progress on Lymphocyte Activation Gene-3 in Gynecological Tumors
BAI Yao-jun
HU Xiao-hong
LI Hong-li
LIU Chang
Abstract：Gynecological tumors are one of the important causes of death among women.Although standard treatments can improve the condition of some patients,many still experience disease progression and poor prognosis.Early diagnosis and treatment are crucial for improving the prognosis of gynecological tumors and reducing the burden of disease.Therefore,identifying more effective therapeutic targets is essential.Lymphocyte activation gene-3(LAG-3)is an emerging immune checkpoint molecule that is highly expressed on the surface of tumor infiltrating lymphocytes in various types of tumors.It participates in immune suppression and tumor immune evasion by inhibiting the function of immune cells.Recent studies have shown that LAG-3 is highly expressed in gynecological tumors and is closely associated with tumor development,making it a promising new target for immunotherapy in gynecological tumors.This review outlines the structure and function of LAG-3 and discusses the research progress on its association with the three major gynecological tumors,providing new insights for future therapeutic research in gynecological tumors.
Keywords：Genital neoplasmsfemaleImmune checkpoint inhibitorsAntineoplastic agentsTumor microenvironmentImmunotherapyLymphocyte activation gene-3
Publication Date：2024-10-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 566-571 )