Application of Microfluidic Technology in Ovarian Cancer Disease Modeling,Drug Evaluation,and Precision Medicine
ZHANG Jian-nan
GUO Xin
GUO Nan
NING Wen-ting
YU Hong-xin
SHANG Hai-xia
Abstract：Ovarian cancer is the third most common malignant tumor of the female reproductive system worldwide,with a five-year survival rate of only 40％.The lack of early diagnostic methods and chemotherapy resistance are significant challenges in the diagnosis and treatment of ovarian cancer.Microfluidic technology,an integrated analytical technique that uses microchips to control fluid flow,offers notable advantages such as high sensitivity,high throughput and low cost.Additionally,this technology can simulate the tumor microenvironment at the micro/nanoscale,facilitating the study of interactions between tumor cells and the immune system.In recent years,microfluidic technology has been widely used in medical research,drug development,and precision medicine,among other areas of life science.In the context of ovarian cancer research,microfluidic technology can be utilized for tumor modeling,early detection of tumor biomarkers,and screening of anti-cancer drugs,providing innovative perspective and future directions for early diagnosis and precision treatment of ovarian cancer.
Keywords：Ovarian neoplasmsLab-on-a-chip devicesTumor microenvironmentDrug screening assaysantitumorPrecision medicineMicrofluidic technology
Publication Date：2024-10-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 560-565 )