The Value of Early Pregnancy Fasting Serum ANGPTL-2 and ANGPTL-8 Levels in Predicting Gestational Diabetes Mellitus Based on Propensity Score Matching

ZHANG Yong-qing; CHEN Dan-qing; CHEN Lu-ping; MA Xin-rui; CAI Wang-ying; WANG Mei-lin

doi:10.12280/gjfckx.20240680

Abstract：Objective:To investigate the predictive value of serum angiopoietin-like protein-2(ANGPTL-2)and ANGPTL-8 levels in early pregnancy for gestational diabetes mellitus(GDM)in pregnant women.Methods:A prospective study was conducted to collect data from 135 pregnant women in early pregnancy(10-13 weeks)who attended prenatal check-ups at Linhai Maternal and Child Health Hospital from July to December 2023.Venous blood was drawn,and based on inclusion and exclusion criteria,a total of 114 pregnant women were enrolled.According to the OGTT results at 24-28 weeks of gestation,participants were divided into the GDM group(15 cases)and the control group(99 cases).Propensity score matching(1:1)was performed according to maternal age and parity,resulting in 14 successful matched pairs(14 cases in the GDM group and 14 cases in the control group).Serum levels of ANGPTL-2 and ANGPTL-8 were compared between the two groups,and Pearson correlation analysis was conducted to determine the correlation of these protein levels with clinical indicators in pregnant women.Receiver operating characteristic(ROC)curve analysis was performed to assess the predictive value of the two proteins for GDM.Results:Serum levels of ANGPTL-2 and ANGPTL-8 were significantly higher in the GDM group than in the control group(both P＜0.05).Pearson correlation analysis indicated that both ANGPTL-2 and ANGPTL-8 were positively correlated with fasting blood glucose levels during the OGTT(r=0.537,P=0.003;r=0.394,P=0.038,respectively).ROC curve analysis revealed that the areas under the curve(AUC)for predicting GDM occurrence were 0.75(95％CI:0.57-0.93)for ANGPTL-2 and 0.79(95％CI:0.61-0.97)for ANGPTL-8,while the combined predictive AUC was 0.81(95％CI:0.65-0.91).Conclusions:Serum levels of ANGPTL-2 and ANGPTL-8 in early pregnancy can serve as early predictors for GDM,facilitating the early identification and management of GDM.