Research Progress on Exosomes in the Diagnosis and Treatment of Premature Ovarian Failure
GUO Pei-yi
ZHU Xue-hong
LIU Hui-xing
LU Li-miao
LIN Zhong
Abstract：Premature ovarian failure(POF)is an endocrine disorder with an increasing incidence in recent years,often leading to decreased female fertility and various postmenopausal symptoms.The etiology of POF remains unclear,and current treatment options are limited,necessitating new approaches to improve ovarian function and enhance fertility in affected women.Exosomes are nano-vesicles that carry a variety of active substances and participate in intercellular signal transmission,exhibiting strong targeting and specificity.Studies have revealed significant differences in certain exosomes between normal and PDF tissues,suggesting their potential as biomarkers for diagnosing POF.Additionally,exosomes may play a crucial role in POF treatment by affecting granulosa cells,promoting hormone secretion,angiogenesis,and combating oxidative stress.This review summarizes the research progress on the relationship between exosomes and POF,aiming to provide a reference for future studies on the role of exosomes in POF.
Keywords：Primary ovarian insufficiencyExosomesDiagnosisTherapy
Publication Date：2024-10-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 492-496 )