Hormonal Pathways and Regulatory Factors That Lead to Endometrial Disease
GUO Xi
WEI Jia
YANG Yong-xiu
Abstract：The development and function of the endometrium are highly dependent on the cyclic secretion of steroid hormones and the expression of their homologous receptors,the most important of which are estrogen and progesterone and their receptors.Estrogen and progesterone enable the endometrium to have a proliferative and secretory phase,maintain a normal menstrual cycle,and prepare for pregnancy.Dysregulation of estrogen and progesterone can lead to a series of diseases such as endometrial cancer,endometrial hyperplasia,and endometriosis,causing serious health problems.Under pathological conditions,estrogen interacts with estrogen receptors to promote excessive proliferation of the endometrium,which is closely related to the increased risk of endometrial lesions.However,progesterone can effectively inhibit the proliferative effect of estrogen,but when the expression of progesterone receptors is abnormal or when progesterone resistance occurs,it can lead to progesterone dysfunction.Effective treatment of endometrial-related diseases depends on the understanding of hormone pathways.This article reviews the hormone pathways and regulatory factors that cause endometrial diseases,with a view to providing reference for the clinical development of new drugs that can effectively prevent and improve treatment outcomes of endometrial diseases.
Keywords：Endometrial neoplasmsEndometrial hyperplasiaEndometriosisGonadal steroid hormonesSignal transductionMolecular targeted therapy
Publication Date：2024-08-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 395-400 )