Research Progress on the Mechanism of Tumor Resistance in Polyploid Giant Cancer Cells
DING Yi-ling
LU Di
SONG Dian-rong
Abstract：Chemotherapy is a commonly used method for tumor treatment,which has a positive effect in the early stage of tumor treatment.However,as the chemotherapy course increases,the sensitivity of tumor cells to chemotherapy drugs gradually weakens,leading to chemotherapy resistance.Tumor drug resistance is a complex process mediated by multiple factors,which is currently believed to be related to tumor cell stemness,heterogeneity,tumor immune microenvironment,and increased chemotherapy drug transport and efflux.But the specific mechanism is not yet clear.Polyploid giant cancer cells(PGCCs)are a special subset of tumor cells with increased volume and abundant nuclei.Research has found that PGCC generally exist in colorectal cancer,breast cancer,ovarian cancer and other tumors,and were closely related to the occurrence,metastasis,drug resistance and recurrence of tumors.This paper describes the formation and significance of the research progress of PGCC in tumors,and expounds the possible mechanism of PGCC causing drug resistance from the perspective of its special mechanism,autophagy,aging and DNA repair,so as to provide a possible strategy for improving tumor drug resistance.
Keywords：NeoplasmsPolyploid giant cancer cellsDrug resistanceneoplasmAutophagyDNA repair
Publication Date：2024-08-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 361-365 )