Application of 3D Printed Hydrogel Stents in Prevention and Treatment of Intrauterine Adhesion
SHI Ming
SUN Ming-hui
YANG Wei-wei
HUANG Hui-hua
ZHANG Chang-lin
David YB Deng
Abstract：Intrauterine adhesion(IUA)often leads to amenorrhea,infertility,and recurrent miscarriage,seriously affecting the physical and mental health of women.Clinically,surgical separation is the main treatment for IUA,but this approach frequently results in postoperative recurrence and has poor treatment efficacy.3D bioprinted scaffolds have emerged as a cutting-edge approach in the treatment of IUA,capable of separating damaged areas to prevent adhesion formation and undergoing controllable in vivo degradation without the need for surgical removal.These scaffolds can be used for drug loading,stem cell transplantation,and exosome delivery,enabling the release of drugs or growth factors to the injured area to promote tissue repair and regeneration.Transplanting 3D bioprinted hydrogels loaded with stem cells or stem cell-derived exosomes to the damaged area can effectively promote the repair of IUA and improve pregnancy rates.3D bioprinting can provide personalized treatment plans for patients,and the combined treatment strategy with stem cells or stem cell-derived exosomes holds promise as a powerful tool for treating IUA.
Keywords：Intrauterine adhesionPrintingthree-dimensionalStem cellsTherapyEndometrial repair
Publication Date：2024-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 290-297 )