Role of E-Cadherin in Peritoneal Implantation and Metastasis of Ovarian Cancer
QI Qi
GAO Ya-ting
XU Fei-xue
Abstract：Ovarian cancer is one of the important causes of cancer death in women,and the main reason for its poor prognosis is that ovarian cancer is prone to recurrence and metastasis in a short period of time.Metastasis of ovarian cancer involves many aspects,such as intercellular junction,angiogenesis,tumor microenvironment and so on.It has been found that epithelial cadherin(E-cadherin)is an important factor in the metastasis of ovarian cancer,which can participate in the metastasis of ovarian cancer by changing cell-cell adhesion,promoting angiogenesis,regulating the process of epithelial-mesenchymal transition,and promoting tumor invasion and infiltration.The structure and expression of E-cadherin in ovarian cancer will be described in detail,and the implantation and metastasis mechanism of ovarian cancer and the role of E-cadherin in ovarian cancer metastasis are reviewed,in order to provide new ideas for recurrence monitoring and follow-up treatment of ovarian cancer.
Keywords：CadherinsOvarian neoplasmsCarcinomaovarian epithelialNeoplasm metastasisEpithelial-mesenchymal transition
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 210-214 )