The Effects of TNF-α and IL-6 on Skeletal Muscle of Fetuses with Fetal Growth Restriction
WANG Yan
WANG Ya-hui
PEI Fei
Abstract：Fetal growth restriction(FGR)is a common obstetric condition and resulting in low birth weight and reduced muscle mass in newborns after birth.This may be closely related to the regulatory mechanisms of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6).Studies have found that these two inflammatory factors are expressed at abnormal levels in FGR fetuses,affecting the proliferation and differentiation of myoblasts,interfering with the normal development of skeletal muscle.Moreover,TNF-α and IL-6 can activate specific signaling pathways,such as nuclear factor-KB(NF-κB),Janus kinase/signal transducer and activator of transcription(JAK/STAT),mitogen-activated protein kinase(MAPK),and other signaling pathways that regulate myocyte metabolism and function.Using specific anti-inflammatory drugs or biological agents to reduce the activity of TNF-α and IL-6 may help improve the skeletal muscle development in FGR fetuses.Overall,the role of TNF-α and IL-6 in the skeletal muscle development of FGR fetuses is a multifaceted and complex process,requiring further in-depth research to clarify their specific mechanisms,aiding to the understanding of the pathophysiology of FGR,and providing new ideas for the treatment of FGR fetuses.
Keywords：Interleukin-6Tumor necrosis factor-alphaFetal growth retardationSignal transductionMuscleskeletal
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 161-166 )