The Etiology of Fetal Growth Restriction and Its Effects on the Long-Term Health of the Child
WANG Ya-hui
WANG Yan
PEI Fei
Abstract：Fetal growth restriction(FGR)is one of the common and more complex complications of pregnancy,which refers to the inability of the fetus to reach its expected growth potential during pregnancy.The etiology of FGR is complex and varied,and may be caused by maternal,fetal or placental factors.Long-term follow-up studies of pediatric and adult patients with FGR have revealed adverse health outcomes.Fetuses with growth restriction lag significantly behind normal children in birth weight and length after delivery,and the vast majority of these children begin to experience significant growth catch-up early in life,but are at higher risk for metabolic problems.FGR is often associated with a range of long-term complications,such as neurologic deficits and abnormalities in skeletal muscle growth and metabolism,and is even associated with increased risk of metabolic syndrome and cardiovascular disease in adulthood.This has a serious impact on the physical health and quality of life of children with FGR.We summarize the pathogenic factors of FGR and its effects on the long-term health of children in order to provide theoretical support for the clinical prevention and treatment of FGR.
Keywords：Fetal growth retardationEmbryonic developmentNeurodevelopmental disordersMusculoskeletal developmentMetabolic syndrome
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 152-156 )