Research Progress into the Role of TLR4 at the Maternal-Fetal Interface in Pre-Eclampsia
HUANG Xiao-tong
CHENG Xiang-wei
ZHANG Yang
Abstract：Pre-eclampsia is a pregnancy complication with multiple organs and system injuries,seriously impairing maternal and fetal health.Nevertheless,the etiopathogenesis of pre-eclampsia has not been fully elucidated yet.In normal pregnancy,Toll-like receptor 4(TLR4)at the maternal-fetal interface regulates the homeostasis of the inflammatory-immune microenvironment.In pre-eclampsia,abnormal TLR4 signaling at the maternal-fetal interface not only mediates deviated inflammatory-immune reaction,but also interacts with other novel pathological phenomena,including ferroptosis,pyroptosis,metabolism reprogramming,and cellular senescence.Furthermore,TLR4 at the maternal-fetal interface may mediate the abnormal development of the nervous system in the offspring.In addition,targeting TLR4 at the maternal-fetal interface may be one of the potential pharmacological mechanisms for new therapeutic research in pre-eclampsia.Based on recent relevant literature,this article explores the multiple possible roles of TLR4 at the maternal-fetal interface in pre-eclampsia and provides reference for the study of the pathogenesis and therapies of pre-eclampsia.
Keywords：Pre-eclampsiaToll-like receptor 4Maternal-fetal exchangeInflammationChemokinesMaternal-fetal interface
Publication Date：2023-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 689-694 )