Research Progress on Sphingolipid Metabolism and Benign and Malignant Gynecological Diseases
LI Zhen-ying
SUN Xiao-tong
XING Guang-yang
LI Jing-jing
LIU Ting-ting
ZHANG Yi-fan
Abstract：Gynecological diseases are one of the causes that threaten women's health.The incidence and mortality rate of gynecological malignant tumors are in the forefront among various systemic diseases in women,and the prognosis of the disease is poor due to tumor recurrence and drug resistance.Sphingolipids are important substances that make up plasma lipoproteins and are essential for various cellular functions and signaling.Sphingolipid metabolism is involved in regulating inflammatory responses and the proliferation,migration,invasion and metabolism of cancer cells.Studies have confirmed that there are differences in the levels of sphingolipids and their metabolites in benign and malignant gynecological diseases,including ceramides,sphingomyelin,sphingosine-1-phosphate and sphingosine.Abnormalities in sphingolipid levels can affect disease progression and sensitivity to chemoradiotherapy,analyzing sphingolipid metabolism may predict the outcome of disease.The review summarizes the research progress of sphingolipid metabolism in benign and malignant gynecological diseases to gain an in-depth understanding of the characteristics and functions of sphingolipids,which can provide new insights for exploring and discovering the pathogenesis,diagnosis,treatment and prognosis of benign and malignant gynecological diseases,in order to improve the treatment prospects and prolong the survival of patients.
Keywords：SphingolipidsUterine cervical neoplasmsEndometrial neoplasmsOvarian neoplasmsEndometriosisLeiomyomaPolycystic ovary syndrome
Publication Date：2023-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 649-654 )