The Effect of Bisphenol A on the Pathogenesis of Polycystic Ovary Syndrome
SUN Yi-wen
XIONG Ke
ZHANG Zi-xu
WENG Ya-jing
WANG Yong
Abstract：Polycystic ovary syndrome(PCOS)is a common endocrine disease characterized by hyperandrogenic phenotype in women of reproductive age.The pathogenesis of PCOS remains unclear,and androgen is now thought to have an essential impact on the pathogenesis of PCOS.Bisphenol A(BPA),an environmental endocrine disruptor,can increase the relevant androgen synthetase and induce PCOS through excessive androgen exposure.Studies have shown that BPA exposure can inhibit the activity of aromatase,prevent the binding of androgen and receptor,thus inducing hyperandrogenemia.BPA can also regulate the ovarian function of PCOS through oxidative stress,estrogen-related pathways,hypothalamic-pituitary-ovarian axis,regulation of obesity and insulin resistance,and other routes.This article aims to review the neuroendocrine mechanism and related signal pathways of BPA-induced PCOS by regulating hyperandrogen,clarify the specific biological functions of BPA and provide a reference for follow-up research.
Keywords：Bisphenol AReceptorsestrogenPolycystic ovary syndromeEndocrine systemandrogen
Publication Date：2023-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 601-605 )