Advances Research in Fetal Growth Restriction

WANG Ming-yu; CHENG Lan; CUI Hong-yan

doi:10.3969/j.issn.1674-1870.2018.03.004

Abstract：Fetal growth restriction (FGR) is a complex and multifactorial disease. The causes include maternal factors, fetal chromosomal or structural abnormalities, and placental dysfunction. It is significantly related to the morbidity and mortality of perinatal infants, and may have an important impact on the prognosis of perinatal infants, affecting the physical development and neuro development in children and adolescents, and causing adult cardiovascular disease. The most dangerous factor is long-term neurologic prognosis, but it is not clear that to what extent the fetus will have neurodevelopmental dysplasia. Doppler is noninvasive and its hemodynamic index is the main means to diagnose and monitor FGR. The changes in the Doppler blood flow of the umbilical artery, the middle cerebral artery, and the ductus venosus under the condition of FGR provide important diagnostic and prognostic information, while the Doppler parameters of ductus venosus is recommended by most European perinatal associations as effective means to manage FGR before 32 weeks. Though Doppler has been studied deeply in the field of FGR, it is still controversial in the management guide. It is not recommended to manage FGR alone. We should focus on the treatment of FGR, the prediction of the possible diseases of the children even adults with the history of FGR, and the primary prevention and reduction of the incidence of the disease in the future research.