Research Progress of PPAR γ in Endometrial Cancer
HUANG Mei-mei
MAO Xiao-dan
Abstract：Peroxisome proliferator-activated receptors(PPARs)are members of nuclear-hormone-receptor family which including PPARα,β/δ and γ. As a hotspot of researches in recent years, PPAR γ is closely related to a variety of metabolic diseases and tumors,which plays an important role in metabolism of lipid and carbohydrate.It functions as ligand-dependent transcription factors,connected with the proliferation,invasion and migration of endometrial cancer cells.The role of PPAR γ in tumorigenesis of endometrial cancer remains unclear. In this article, we reviewed studies progress of PPAR γ in endometrial cancer,discussing the role of PPAR γ in tumorigenesis of endometrial cancer and potential mechanism underlying endometrial cancer development and furthering propose theoretical basis for anti-tumor therapy.
Keywords：PPAR gammaEndometrial neoplasmsRetinoid X receptorsSignal transductionPeroxisome proliferator-activated γ agonist
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 80-84 )