Advances in Inflammatory Causes of Preterm Birth
GENG Qian
CHANG Ying
Abstract：Preterm birth (PTB)is a common obstetric complications and it is greatly harmful to mothers and fetals.At present, the mechanism of PTB is not clear. The present research shows that the inflammatory response, especially the inflammatory mediators,plays an important role in the initiation of PTB.The inflammatory mediators on one hand promote the synthesis of prostaglandin and induce uterine contractions, on the other hand promote cervical ripening and trigger matrix metalloproteinases to degrade extracellular matrix,reduce toughness of fetal membranes.The combined effect of all above finally cause uterine contraction,cervical ripening,rupture of fetal membranes,leading to PTB.Microbial infection and the oxidative stress, inhibited autophagy can cause inflammation. PM2.5 may induce mild intrauterine inflammation, resulting in PTB. Mechanism of PTB is unknown and this article will review the mechanism from three aspects.They are the related molecules in inflammation-mediated PTB,the biological and non-biological pathways inducing inflammation.
Keywords：Premature birthFetal membranespremature ruptureInfectionCytokinesNonbiological factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 19-22 )