Research Progress on Exosome in the Diagnosis and Treatment of Malignant Gynecologic Tumors
WU Ruo-yu
JIA Xiang
CAO Yi-meng
Abstract：Exosomes are nano vesicles with lipid bilayer structures which are derived from live cells. With various DNAs, RNAs and proteins inside, exosomes are widely involved in many physiological and pathological processes, such as information transfer and material exchange between cells. They can not only reflect the physiological and functional state of cells, but also play important roles in the regulation of tumor occurrence, development, invasion and metastasis. Exosomes derived from malignant tumor cells such as ovarian cancer, cervical cancer and endometrial cancer can be extracted from blood, vaginal lavage fluid, uterine lavage fluid and other body fluids with specificity by none-invasion procedure and can be used to extract tumor exosomes derived miRNAs and other biomarkers with fluid biopsy. Exosomes are recognized as novel means in the early screening, diagnosis and curative effectiveness evaluation of gynecologic malignancies. Tumor cells can acquire drug resistance by excreting chemotherapeutics via exosomes. Also, exosomes can be used as new routes of administration and improve the efficacy of anti-tumor drugs.
Keywords：Genital neoplasmsFemaleDiagnosisTherapyExosome
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 276-279 )