Regulation of Autophagy in Ovarian Cancer Cells by Signaling Pathways of EGFR
LI Yan
TANG Xiao-han
Abstract：EGFR is the epidermal growth factor receptor,and its downstream signaling pathways affect many physiological activities of ovarian cancer cells,including the regulation of autophagy.Autophagy is a process of cell self digestion,which is not only the self protection mechanism of cells under adverse conditions,but also can induce cell death and drug resistance.In ovarian cancer cells,EGFR-Ras-Raf-JNK,EGFR-PI3K-Akt-mTOR,and EGFR-JAK-STAT3 three pathways both promote and inhibit activation of autophagy.In recent years,EGFR inhibitors attempt to block the EGFR signaling pathways and inhibit autophagy activity and reverse drug resistance.The aim of this review is to illustrate the regulatory role of EGFR three main signaling pathways in the regulation of autophagy in ovarian cancer cells,and to provide a new target for ovarian cancer therapy and anti-drug resistance.
Keywords：Receptorepidermal growth factorSignal transductionOvarian neoplasmsAutophagy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 133-136 )