The Relationship between Hypothyroidism and Hemodynamic Indexes in Pre-eclampsia

LIU Yu; MENG Xiao; YIN Zhi-min; DING Hong-juan

doi:10.3969/j.issn.1674-1870.2017.01.021

Abstract：Objective: To investigate the correlation between hypothyroidism and hemodynamic parameters in pre-eclampsia (PE). Methods: 141 singleton pregnant women from June 2015 to January 2016 in Nanjing Maternity and Child Health Care Hospital were selected and classified into following groups: normal pregnancy group (39 cases), PE group (79 cases) and pregnancy-induced hypertension group (23 cases). Each woman′s thyroid stimulating hormone (TSH), serum free thyroxine (FT4), total protein(TP), albumin(ALB), total cholesterol(TC), triglyceride(TG) levels were tested and compared. Noninvasive hemodynamic monitoring was performed for all patients testing the heart rate (HR), mean arterial pressure (MAP), systolic blood pressure (SBP) and diastolic blood pressure (DBP), cardiac index (CI), cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI) and ET%changes. Results:①The TSH of the participants in PE group, compared with those of the other groups, was significantly increased (P<0.05);The FT4 of the participants in PE group, compared with those of the other groups, was not significantly different (P>0.05);②The TP and ALB of the participants in PE group, compared with those of the other groups, was significantly decreased (P<0.05);The TC of the participants in PE group, compared with those of the other groups, was significantly increased (P<0.05); The TG of the participants in PE group, compared with those of the other groups, was not significantly different (P>0.05);③The HR of the participants in PE group, compared with those of the other groups, was significantly decreased (P<0.05);the SBP, MAP, SVR, DBP and SVRI of the participants in PE group, compared with those of the other groups, were significantly increased (P<0.05);The ET%, CO and CI of the participants in PE group, compared with those of the other groups, were significantly decreased (P<0.05); ④TSH was weakly positively correlated with TC (r=0.259 7,R2=0.002,P<0.05). TSH was weakly negatively correlated with TP and ALB (r=-0.222 5 and-0.367 2, R2=0.011 and 0.134,P<0.05). FT4 was weakly positively correlated with TP and ALB (r=0.171 3 and 0.233 8, R2=0.029 and 0.054,P<0.05).⑤TSH and MAP and SBP were weakly positively correlated (r=0.195 4 and 0.198 2, R2 both were 0.030,P<0.05), FT4 and ET%and HR were weakly positively correlated (r=0.166 2 and 0.175 7, R2=0.027 and 0.030,P<0.05). Conclusions:PE is often associated with hypothyroidism, so it is necessary to check the level of thyroid hormone; And there was a certain correlation between the increase of TSH and the occurrence of PE. TSH fluctuation could provide evidence for early diagnosis and treatment in PE.