Research Progress of Prenatal Screening for Aneuploidy in Twin Pregnancy
YAO Jing-yi
CUI Lan
YUE Sheng
XIN Li
Abstract：The incidence of aneuploidy in twin pregnancy women is higher than singleton pregnancies women, and the prenatal screening effect is influenced by many factors. Zygosity in twin pregnancy is very important, which directly affects the risk calculation models. Normally, we use ultrasound to detect fetal human chorionic. It can indirectly judge the zygosity of twin pregnancy. Currently, the fetal chromosomal aneuploidy screening in twin pregnancy is mainly concentrated in the first trimester nuchal translucency thickness (NT) screening, first trimester combined screening (NT+serum screening),second trimester serum screening, as well as the chromosomal aneuploidy screening by the noninvasive prenatal test (NIPT). These programmes are mainly involved in chromosomal diseases with high incidence of 21-trisomy syndrome and 18-trisomy syndrome. Taking into account the detection rate, the false positive rate and the economic effects, the first trimester combined screening is the main application programme. This article gives an overview of the aneuploidy prenatal screening with twin pregnancy.
Keywords：TwinsChromosomesAneuploidyGenetic screeningPrenatal diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 67-70 )