Research Progress of HtrA Correlation with Pre-eclampsia
KONG Hong-fang
CHANG Ya-qing
WANG Fang
XIN Hong
Abstract：Pre-eclampsia, a major cause of maternal mortality in developing countries, is a peculiar disease during pregnancy. It still holds a central public health concern. Studies have shown that pre-eclampsia is closely related to the cell apoptosis, vasospasm, activation of blood coagulation system, inflammatory reaction and so on. Its pathological change began in the shallow placenta implantation and placental vascular recasting barriers, lead to the placenta tissue ischemia hypoxia, cause endothelial cell damage. High temperature requirement A (HtrA) is one of serine protease family, under stress conditions such as cells to heat shock, oxidative stress, inflammation, ischemia-reperfusion and cancer, degradation of misfolded proteins in the cell cytoplasm, participate in the pathological physiological processes such as cell apoptosis, arthritis, embryonic form, nerve degeneration and neuromuscular disorders and cancer. Studies have shown that the subtypes are closely associated with pre-eclampsia. This paper presents the progress of HtrA associated with pre-eclampsia and its mediated control network, which has an important significance to further understand the pathogenesis of pre-eclampsia and provide a new treatment method.
Keywords：Pre-eclampsiaSerine endopeptidasesHtrA
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 56-59 )