Effect of Immunosuppressive Therapy on HPV Infection and the Incidence of Cervical Cancer after Renal Transplantation
WU Yu-xian
ZHOU Yang
JIN Zhi-jun
Abstract：Objective: By studying the human papilloma virus (HPV) infection rate and cervical cancer incidence in women on immunosuppressive therapy after renal transplantation, compared with that of the gynecological patients, to explore the immunosuppressive therapy effect on high risk type HPV infection and cervical cancer incidence in women after renal transplantation, and provide evidence for early diagnosis and prevention of cervical cancer. Methods: Selection in female patients with renal transplantation, no other organ transplantation, before transplantation without HPV infection and CIN and cervical cancer patients 865 cases as study group. Select gynecological patents in our hospital without organ transplant at the same time as control group. Comparative analysis of the two groups of high-risk HPV infection and cervical cancer incidence. Results:The high-risk HPV infection rate and the incidence of CINⅢand cervical cancer in study group were higher than that in control group, difference was statistically significant (all P<0.001);And the average onset age in high-risk HPV infection, CINⅢ and cervical cancer had no statistical significance difference in the two groups (all P>0.05). Conclusions:Immunosuppressive therapy after renal transplantation will not make early onset age in HPV infection and cervical cancer, but may result in increased incidence of the disease.
Keywords：Kidney transplantationPostoperative periodImmunosuppressive agentsPapillomaviridaeUterine cervical neoplasms
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 52-54 )