Progress of Diagnosis and Treatment of Large Cell Neuroendocrine Carcinoma of the Uterine Cervix
LI Jun-min
XI Yong
GAO Jing-chun
Abstract：Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare but highly aggressive malignancy that tends to spread and recur early even in its early stage. The prognosis is very poor despite multimodal treatments. The clinical symptoms of LCNEC of the uterine cervix are similar to others kinds of cervical cancer. And the accurate diagnosis requires tissue pathology and immunohistochemistry for nueroendocrine markers. Neuroendocrine carcinomas sometimes are infected with high-risk human papillomavirus (HPV), but they are the subtype of cervical cancer that does not appear to be associated with HPV exposure. Because of the aggressive nature of LCNEC of the uterine cervix, the expert examine the patients more frequently in the postreatment period. The overwhelming majority of available data related to its treatment derive from retrospective analyses or small case series. LCNEC of the uterine cervix seem to behave similarly to their more common counterpart, small cell neuroendocrine carcinoma of the uterine cervix. So the treatment of LCNEC is refer to the small cell neuroendocrine carcinoma of the uterine cervix, which is the combination of management (surgery+chemotherapy ±radiation). The combination can prolong the life time of the patient. Because of their peculiar clinical and biological features and the lack of literature data, there is an urgent need to study LCNEC of the uterine cervix.
Keywords：Uterine cervical neoplasmsCarcinomaneuroendocrineDiagnosisTreatmentPrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 40-43 )