Lynch Syndrome and Gynecologic Oncology

WANG Tian-tian; ZHANG Rong

Abstract：Lynch syndrome, an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most prevalent hereditary modality of colorectal cancer. Patient with Lynch syndrome are often diagnosed more than one kind of cancer, such as endometrial cancer or ovarian cancer, which can function as a"sentinel"cancer in Lynch syndrome. For women with Lynch syndrome, the lifetime risk of endometrial carcinoma (EC, up to 60%) may exceed their risk of colorectal cancer (CRC). It is an efficient strategy to combine clinical criteria with immunohistochemistry assessment. By means of endometrial biopsy(1 to 2 years, not every year) and risk-reducing surgery after delivery, women with Lynch syndrome will get efficient screening and prevention. And we are continually getting new discoveries of Lynch syndrome and Lynch syndrome related endometrial cancer and ovarian cancer. In this review, we summarized the clinical criteria of screening the Lynch syndrome and the characteristics of Lynch syndrome related endometrial cancer and ovarian cancer.