Research Progress of Copy Number Variation in Gynecological Malignant Tumors
KANG Ya-fang
SUN Peng-ming
Abstract：Copy number variations (CNVs) can serve as significant disease susceptibility markers in many disorders. The availability of a large number of chromosomal copy number profiles in both malignant and normal tissues in cancer patients presents an opportunity to characterize not only somatic alterations but also germline CNVs, which may confer increased risk for cancer. The determination methods of CNVs mainly includes the gene chip technology, high throughput sequencing, real-time quantitative PCR and FISH, etc. The most important method is the gene chip technology. At present the study of CNVs in gynecologic malignant tumor is relatively limited. The article focus on researching that CNVs is closely related to some tumor disease of gynaecology, such as ovarian cancer, cervical cancer, endometrial cancer. Comprehensive mining of copy number variations and bioinformatics analysis, understanding of the progress of the gynecological malignant tumors, degradation mechanism, and provide new ideas and methods for tumor prevention, diagnosis and treatment.
Keywords：Variation (genetics)Oligonucleotide array sequence analysisPolymerase chain reactionOvarian neoplasmsUterine cervical neoplasmsEndometrial neoplasms
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 493-496 )