The Relationship between Inflammation and Endometrial Cancer

LI Li-li; FAN Jiang-tao

Abstract：Recent evidences show that inflammation plays a significant role in the development of endometrial cancer. Overexpressing of inflammatory factors is often closely related to the diseases. Studies detected that serum inflammatory factor level in cancer patients is higher than normal people. Inflammatory mediators in the tumor microenvironment are conducive to the tumor proliferation, migration and angiogenesis. And the chemokine might inhibit the apoptosis of tumor cells through the inflammatory signaling pathways. So is in endometrial cancer. Inflammation can promote the development of the endometrial cancer through a variety of inflammatory factors and inflammation cells, and endometrial cancer also shows a variety of inflammatory features, which can help the cancer cells to proliferate and metastasize. Inhibiting inflammatory pathways may become a kind of interventions for the treatment of endometrial cancer. So it is important to explore the correlation between inflammation and endometrial cancer. This paper reviewed the relationship between inflammation and endometrial cancer, providing a new method for the treatment of endometrial cancer.