Clinical Value of Soluble Fms-like Tyrosine Kinase-1,Placental Growth Factor,25-hydroxyvitamin D,D-dimer,von Willebrand Factor,P-selectin for the Risk Assessment of Preeclampsia during the First Trimester of Pregnancy
HE Xue-yi
WANG Chen-hong
Abstract：Objective:To evaluate the signification of serum soluble fms-like tyrosine kinase-1 (sFlt-1),placental growth factor(PlGF),25-hydroxyvitamin D(25-OH-VD),D-dimer,von Willebrand factor(vWF),P-selectin for predicting risk of pre-eclampsia (PE) during the first trimester of pregnancy. Methods:In this nested cohort ,we recruited 1 081 consecutive women who presented for antenatal care between 10 and 13+6 weeks of gestation from Shenzhen Maternity and Child Healthcare Hospital from January 2013 to December 2013. Of the 1 081 pregnant women studied,50 patients were diagnosed with PE as case group. There are 352 normal pregnant women without complications as control group. Serum sFlt-1,PLGF,25-OH-VD, D-dimer,vWF and P-selectin were detected by ELISA. Using ROC curve to evaluate the value of diagnosis preeclampsia for the six index alone or combination. Results:During 10-13+6 weeks of gestation serum levels of sFlt-1,D-dimer,vWF,P-selectin of gravida with PE were significantly higher than the control group (P<0.05). The serum PlGF and 25-OH-VD levels in case group was significantly lower than that in the control group (P<0.05). Combining total multiple of median (MoM) of serum sFlt-1,PlGF,25-OH-VD,D-dimer,vWF,P-selectin using ROC curve analysis can get a sensitivity of 78%and a specificity of 100%for predicting the risk of PE. Conclusions:Combining screening of different biomarkers such as serum sFlt-1,PlGF,25-OH-VD,D-dimer,vWF and P-selectin could increase the predictive value of PE at the first trimester pregnancy.
Keywords：Pre-eclampsiaVascular endothelial growth factor receptor-1Placental growth factorCalcifediolD-dimervon Willebrand factorSelectins
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 308-311 )