Effects of Phytic Acid Ketone on the Cell Proliferation of HeLa and Caski

GAO Xiao-li; WANG Kan; TIAN Wen-yan; YUE Tian-fu

Abstract：Objective:To investigate the proliferation inhibitory effects of different density Phytic Acid Ketone on cervical cancer cell HeLa and Caski. Methods:Use the culture medium to dilute the type II No.1 and No.2 Phytic Acid Ketone to different density. The HeLa (adeno carcinoma, HPV 18 genome integrated) and Caski (squamous carcinoma, HPV 16 genome integrated) cells were treated with different concentration and time of Mefordcare. The inhibitory effects were evaluated with MTT assay. Results:The growth of HeLa and Caski was inhibited by different concentration of Mefordcare Phytic Acid Ketone, which was concentration-time dependent. The inhibitory effect on HeLa and Caski of Phytic Acid Ketone No. 1 and No. 2 varied with the concentration used, and the inhibitory rate came to the peak when concentration was about 5 860 mg/L and 5 500 mg/L. The inhibitory rate of cell proliferation was significantly different with the treating time at the same concentration (P<0.05). Conclusions:There were inhibitory effects from Phytic Acid Ketone on the growth of cervical cancer cell line HeLa and Caski. The result provides theoretical basis for the clinical application of Mefordcare Phytic Acid Ketone.