Updates of Patient Derived Xenografts Model in Ovarian Tumors

WU Jian-fa; YI Xiao-fang

Abstract：Ovarian cancer has the highest motality among the female reproductive malignancies. The underling mechanism is still unknown, and the prognosis has not been improved significantly. To establish an ideal preclinical model is in favor of the study of recurrence and metastasis in ovarian cancer. Recently, the development of patient derived xenografts model gives us a new platform for preclinical study. Gradually it has been used in the study of breast cancer, lung cancer and colon cancer, where it is proved to be useful. Much less studies on the use of patient derived xenografts model in ovarian cancer has been reported and data was shown promising. Based on the existing literature retrieval, this model could better copy the biological characteristics of the primary tumor and keep the heterogeneity of primary tumor. But there were still some problems need to be solved in the application of it, such as the different tumor take rate, the limited tumor resources and the lack of effective quality control standards. Here this review aims to address the application status, existing problems and application prospects of this model.