Study on the Placental Expression of BSEP in Intrahepatic Cholestasis of Pregnancy
GU Li-ping
LIU Xiao-hui
SONG Ye
HOU Shun-yu
DAI Jian-rong
Abstract：Objective:To explore the expression of bile salt export pump(BSEP) in placenta tissue and its relationship with intrahepatic cholestasis of pregnancy (ICP). Methods:The expression of BSEP in the placenta was detected by immunohisto-chemistry and western blotting respectively in 30 women with ICP (ICP group) and 30 normal gravidas (control group) from February 2012 to August 2013 in Department of Obstetrics of Suzhou Municipal Hospital. Results:BSEP was located at the cytoplasm in the placental trophoblastic cells. The expression of BSEP in ICP group was significantly lower than control group [(0.197 7±0.111 8) vs. (0.616 0±0.384 9),P<0.001]. Conclusions:Decreased expression of BSEP in placenta may be asso-ciated with ICP.
Keywords：CholestasisintrahepaticPregnancyPlacentaBile acids and salts
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 42-44,后插1 )