The Study of the CD28/CTLA-4 Disturbance in Early-onset Severe Preeclampsia Prior to Delivery and after Parturition
ZHANG Na-na
LYU Ying-pu
YANG Shi-fang
CHEN Yan-jun
ZHANG Wen-zhen
LI Cong-wei
Abstract：Objective:To study the alteration of the leukocyte differentiation antigens 28/cytotoxic T lymphocyte antigen 4 (CD28/CTLA-4) in maternal blood lymphocyte from patients with early-onset severe preeclampsia to investigate the function of CD28/CTLA-4 in the pathogenesis of early-onset severe preeclampsia. Methods:Peripheral blood from 30 patients with early-onset preeclampsia (PE) [prior to delivery (PTD) and after parturition (AP)]. It applies flow cytometry to detect expression of CD28/CTLA-4 of peripheral lymphocytes in CD4+T and CD8+T cells. At the same time, to determine blood pressure and the functions of liver and kidney. Results:The CD3+CD4+CTLA-4+, CD3+CD8+CTLA-4+cells in early-onset severe preeclampsia before delivery above after childbirth, CD3+CD4+CD28+/CD3+CD4+CTLA-4+, CD3+CD8+CD28+/CD3+CD8+CTLA-4+below after childbirth, was statistically significant (P<0.05). There isn′t correlation between the CD3+CD4+CD28+/CD3+CD4+CTLA-4+and CD3+CD8+CD28+/CD3+CD8+CTLA-4+ (r=-0.037, P=0.844). Conclusions:After parturition, the station about the decrease of CTLA-4 and the increase of CD28/CTLA-4 might be relation to early-onset preeclampsia.
Keywords：Pre -eclampsiaAntigensCD28T -lymphocyte subsetsTh1 cellsTh2 cellsParturitionCytotoxic T -lymphocyte-associated antigen 4
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 533-535 )