Endometriosis Stem Cells and Wnt/β-catenin Signaling Pathway
LIU Jun
ZHAO Zhi-mei
XIA Tian
YAO Xiu-jie
Abstract：Endometriosis (EMs) is characterized as class neoplastic disease because of its invasiveness,easy to relapse and other neoplastic diseases character. In recent years ,with the development of EMs etiology study ,the existence of stem cells in the endometrium and these stem cells are involved in the endometrial cyclical activities have been proposed and validated ,and then EMs stem cell theory is gradually being recognized. In the research of stem cell as the application of molecular biology method,a growing number of genes and signaling pathways involved in stem cells proved to be take part in stem cell′s cyclical activity,of which Wnt/β-catenin signaling pathway is one of the most important research pathways of stem cells. Wnt/β-catenin signaling pathway is highly conserved in its structural complexity in the development of a variety of tumors by stem cell proliferation cycle play a role,meanwhile Wnt/β-catenin signaling pathway involved in endometrial stem cell regulation,which would provide new ideas for the occurrence, development and treatment of endometriosis.
Keywords：EndometriosisStem cellsSignal transductionβ-catenin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 409-412 )