The Relationship between Serum Uric Acid Level and Hypertensive Disorder Complicating Pregnancy

CHEN Ji-ming; GAO Hong-yan; WANG Yun; CHEN Da-li; CHAI Li-qiang

Abstract：Hypertensive disorders complicating pregnancy (HDCP) is a common clinical disease specially correlated to pregnancy,which had serious harm on maternal and child health. The etiology and pathogenesis mechanism of HDCP is not yet entirely clear. The main pathophysiological change of HDCP is systemic small vessel spasm ,endothelial injury and local ischemia. Serum uric acid (UA) is the end product of purine metabolism in human,which is mainly excreted by kidney. Previous studies confirmed that the relationship between HDCP and serum UA was extremely close ,and they had both interaction and influence to each other. It might have an important significance to monitor serum UA level for assessment of the occurrence and development of HDCP,especially preeclampsia. However,there is still no small controversy on the clinical application of serum UA level for the prediction or early diagnosis of preeclampsia. It is not clear whether the predictive value could be effectively improved by combination with a variety of detection indexes and construction of a new detection model. A summarization will be established in this paper on the issues as follows: the basic pathophysiology of HDCP,and the interaction between HDCP and serum UA metabolism. The close relationship between serum UA and the pathogenesis of preeclampsia. The predictive value of serum UA on the clinical diagnosis along with the prognosis of mother and fetus in preeclampsia.