Effect of Prophylactic Carbetocin in Prevention of Postpartum Hemorrhage Following Cesarean Delivery in Women with Hypertensive Disorder Complicating Pregnancy
HAN Ling-xiao
YU Fang
HOU Hai-yan
SHI Hai-xia
WU Tao
YANG Wei-ping
Abstract：Objective:To explore carbetocin in the prevention of postpartum hemorrhage (PPH) following cesarean delivery in women with hypertensive disorder complicating pregnancy. Methods:Prospective randomized control study was carried out on single pregnancy with gestation more than 32 weeks following cesarean delivery. All the cases were randomized to receive either carbetocin (treatment group,n=90) or oxytocin (control group,n=90). Following delivery of each baby,20 IU oxytocin was infusion and 100 microgram carbetocin(treatment group) and 100 microgram oxytocin(control group) were given as myometrium injection. 24 h blood volume of postpartum,blood pressure,birth weight,Apgar scores,maternal heart rate and drug adverse reaction were collected. Results:The estimated blood loss within 24 h in treatment group was significantly lower than control group (P<0.05). The incidence postpartum haemorrhage of treatment and control group had no difference (14.4%vs. 20.0%,P>0.05). There was no difference in birth weight,Apgar scores,neonatal asphyxia and amniotic fluid characteristics between the two groups (P>0.05). There was no significant syndrome of nausea and vomiting. Conclusions:Carbetocin makes better effect than common oxytocin on prevention of postpartum haemorrhage cesarean delivery in women with hypertensive disorder complicating pregnancy ,and no adverse complication was found.
Keywords：OxytocinHypertensionpregnancy-inducedPostpartum hemorrhage
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 423-425 )