Phosphatidylinositol 3-hydroxy Kinase and Endometrial Cancer

WANG Kai-yue; ZHOU Huai-jun

Abstract：Phosphatidylinositol 3-hydroxy kinase (PI3K) signalling pathway specially regulate a range of cellular essential physical processes, including proliferation, differentiation, cell cycle progression ,which is closely bound up to the formation, development and prognosis of various human cancers. Based on the difference of comprising subunits, phosphatidylinositol 3-hydroxy kinase (PI3K) can be divided into three classes, including PI3K classⅠ,ⅡandⅢ. The substrate specificity, as well as the corresponding catalytic product downstream, also differ among such three classes biological effects and lead to specific biological effects. Various subunits of PI3K classⅠalways undergo mutation or amplification, accompanied by predominant carcinogenic potential. PI3K class Ⅱ mainly controls cell proliferation and apoptosis, regulate cell cycle progression and the formation of newborn vessels, whereas PI3K class Ⅲ can induce the autophagy procedure of endometrial glandular epithelial cells and inhibit their excessive proliferation. This article mainly provides a review concerning the specific relationship between pathogenesis of Gynecological cancers, especially endometrial carcinoma and various PI3K regulatory subunits and catalytic subunits.