Relationship between miRNA Regulating Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer
ZHANG Yue
ZHANG Shu
Abstract：Ovarian cancer is a common gynecological malignancy and one of leading causes of cancer-related morbidity and mortality in female patients around the globe. The metastasis of ovarian cancer is an important factor in causing deaths. EMT (epithelial-mesenchymal transition) refers to the transition process from the phenotype of epithelial cells to mesenchymal phenotype and is closely associated with the malignant progression of tumors in its invasion and metastasis. MicroRNA (miRNA) are a class of small molecule and noncoding RNAs which inhibit translation of the mRNA transcript of the genes expression,and become more and more concerned in regulating EMT progress. Many kinds of miRNA expressed abnormally and related to the occurrence and development of ovarian cancer,are expected to be used in early diagnosis,treatment and prognosis. In this review,we presented recent research regarding the role of EMT and related microRNAs in the malignant progression of ovarian cancer.
Keywords：Ovarian neoplasmsCarcinomaEpithelial-mesenchymal transitionMicroRNAsNeoplastic stem cellsNeoplasm metastasis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 390-394,418 )