A Systematic Review for the Preserve Fertility Surgery in Malignant Ovarian Germ Cell Tumor

WEI Ren-ji; LI Li

Abstract：Objective:To evaluate the survival rate, recurrence rate and postoperative pregnancy after fertility preservation operation in patients with malignant ovarian germ cell tumor. Methods:We searched for studies in PubMed and VIP database et al,case control study which conformed to the standards was included and finished quality evaluation. The homogeneity study used RevMan 5.1 software for Meta analysis. Results:We identified 11 retrospective case control trial,which described fertility preservation operation and radical operation in malignant ovarian germ cell tumor and compared their survival. The Meta analysis results:patients with malignant ovarian germ cell tumors after fertility-sparing surgery had a better survival rate than the radical operation ones, the difference was statistically significant (OR=1.88,95%CI:1.32-2.69,P=0.000 5). Malignant ovarian germ cell tumors with preservation of fertility with lower recurrence rate than patients not to preserve fertility operation, the difference was statistically significant (OR=0.11,95%CI:0.03-0.38,P=0.000 7). Only 4 clinical case studies detailed record and analyzed the number of patients who trying to get pregnant and actual successful pregnancy ,and calculate the total pregnancy rate was 86.7%. Conclusions:Preserve fertility operation had a better survival rate and recurrence rate than the radical operation patients with ovarian malignant germ cell tumor ,could maintain the reproductive function and normal pregnancies,improved the quality of patients life.