Expression and Clinical Significance of BRMS1 and NF-κB in Cervical Carcinogenesis

MAO Li; YANG Yong-xiu

Abstract：Objective:To study the protein expression and clinical significance of breast cancer metastasis suppressor l (BRMS1) and nuclear factor kappa B (NF-κB p50) in cervical carcinogenesis. Methods:The immunohistochemical method (Super Sensitive TM IHC)was used to determine expressions of BRMS1 and NF-κB p50 were in chronic cervicitis tissues,CINⅠ tissues,CINⅡ-Ⅲ tissues and cervical carcinoma tissues. The clinical significance was analyzed with histopalthological records. Results:①The positive rates of BRMS1 in cervical carcinoma ,CINⅠand CINⅡ-Ⅲtissues were much lower than that in chronic cervicitis tissues, the differences were significant (all P<0.05),moreover the positive expressions were much lower or absent in cervical cancer tissues withⅡB-Ⅳstage,depth of invasion>1/2 and with lymph node metastasis, the differences were significant (all P<0.05).②The positive rates of NF-κB p50 in cervical carcinoma,CINⅠand CINⅡ-Ⅲtissues were much higher than that in chronic cervicitis tissues(all P<0.05),moreover the positive expressions were much higher in cervical cancer tissues with tumor size≥4 cm,poor differentiation,depth of invasion>1/2 and with lymph node metastasis, the differences were significant (all P<0.05). ③The expression level of BRMS1 was negatively correlated with that of NF-κB p50 in cervical carcinoma (rs=0.426,P<0.001). Conclusions:It is closely related to cancer cell invasion and metastasis that the expression of BRMS1 decreased significantly,while the expression of NF-κB conversely increased. In addition,BRMS1 may inhibit NF-κB expression in invasion and metastasis of cervical cancer.