Progress on Human Papillomavirus Type 58 Research of Cervical Diseases
HU Jia-ni
DING Ai-ping
ZHANG Shu-lan
Abstract：High risk human papillomavirus (HPV) plays a necessary,though insufficient,role in the development of cervical cancer. As one of the high risk HPVs ,HPV58′s infection is very common in East-South Asian area. Thus ,our review mainly focuses on the epidemiology ,carcinogenicity and viral integration of HPV58. We found out that as one of the high risk HPV types,HPV58 is rare worldwide but being found more commonly in East Asia. E6,E7 of HPV58 are the major oncoproteins,which are responsible for the transformation of host cells. Moreover,the integration of HPV58 to the host cell also plays an important role in the transformation of host cells. Thus ,a clear study is of a great significance to the research of the pathogenesis of HPV58 in cervical carcinoma and precancerous lesions and the health of Asian women. Therefore the epidemiology,carcinogenicity and viral integration of HPV58 will be the new host research hot spots.
Keywords：PapillomaviridaeUterine cervical neoplasmsCarcinomaProto-oncogenesVirus integrationEpidemiology
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 137-141 )