Research Progress of miR-17-92 Cluster
YU Yu
ZHANG Shu-lan
Abstract：MicroRNAs (miRNA) are a class of highly conserved small,single-stranded non-coding RNAs that regulate target genes expression by fully or partially complementary principle binds to target genes 3′UTRs or direct shear target genes mRNA. miR-17-92 cluster is located on human chromosome 13q31.3,which encodes miR-17,miR-18,miR-19a,miR-20, miR-19b and miR-92. miR-17-92 cluster controls 30 kinds of target genes ,which involve in cancer development. The paper reviews the structure and function and the roles of miR-17-92 cluster in gynaecology and other tumors occurrence and development.
Keywords：MicroRNAsGenital neoplasmsfemaleMultigene familyGenestumor suppressor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 124-127 )