Study on the the diagnostic value of combined detection of serum CYFRA21-1,TSGF and SCCA in lung cancer
Wang Yanping
Xue Fei
Ma Lufang
Zhou Xiaolei
Abstract：Objective:To investigate the association of serum cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),tumor specific growth factor(TSGF)and squamous cell carcinoma antigen(SCCA)levels with lung cancer histologic sub-types and clinical stages,and to evaluate the diagnostic value of their combined detection.Methods:A total of 151 lung cancer patients admitted to Luohe Second People's Hospital from August 2021 to May 2024 were enrolled as the observation group,along with 134 healthy controls from routine health examinations during the same period.Serum CYFRA21-1,TSGF and SCCA were compared between the two groups.Serum CYFRA21-1,TSGF and SCCA in patients with different patho-logical types and clinical stages of lung cancer were compared.The diagnostic value of CYFRA21-1,TSGF and SCCA alone or in combination for lung cancer was analyzed by drawing the receiver operating characteristic(ROC)curve.Results:The levels of serum CYFRA21-1,TSGF and SCCA in the observation group were significantly higher than those in the control group[CYFRA21-1:(4.36±1.05)μg/L vs.(1.57±0.50)μg/L,t=28.061,P＜0.001;TSGF:(72.42±7.12)U/mL vs.(52.38±5.69)U/mL,t=26.029,P＜0.001;SCCA:(2.06±0.55)μg/L vs.(0.84±0.29)μg/L,t=22.994,P＜0.001].Serum CYFRA21-1 and SCCA gradually decreased in squamous cell carcinoma,adenocarcinoma and small cell lung cancer(P＜0.001),while serum TSGF gradually decreased in small cell lung cancer,squamous cell carcinoma and adenocarcinoma(P＜0.001).In addition,serum CYFRA21-1,TSGF and SCCA gradually increased with the increase of clinical stage(P＜0.001).The area under the curve(AUC)of the combined diagnosis of lung cancer by CYFRA21-1,TSGF and SCCA was 0.912,the sensitivity and specificity were 90.38%and 95.85%,respectively,which were higher than detection of CYFRA21-1,TSGF and SCCA alone(AUC:0.717,0.698 and 0.733,respectively,P＜0.001).Conclusions:The combined detection of CYFRA21-1,TSGF and SCCA in serum of lung cancer patients shows important clinical value in the diagnosis of lung cancer.Moreover,their levels are closely related to tumor type and stage,which is helpful to formulate more accurate treatment plan.
Keywords：Lung cancerCyto-keratin 19 fragment antigen 21-1Tumor specific growth factorSquamous cell carcino-ma antigenDiagnostic valueTumor typeStages
Publication Date：2025-08-28
Online Publishing Date：2025-09-26(First online date of this platform, not the publication date of the document)
Pages：5( 281-285 )