Prediction value of creatine kinase,creatine kinase isoenzyme and cardiac troponin I for delayed encephalopathy after acute carbon monoxide poisoning
Wang Zhiguo
Wan Benjie
Zhang Yuan
He Liang
Emilia Obono
Deng Ying
Abstract：Objective:To evaluate the predictive value of creatine kinase(CK),creatine kinase isoenzyme(CK-MB)and cardiac troponin I(cTnI)for delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods:A retrospective study was conducted on 119 patients with DEACMP admitted to the Second Affiliated Hospital of Harbin Medical University from February 2018 to February 2025.According to occurrence of DEACMP,the patients were divided into a good prognosis group(97 cases)and a poor prognosis group(22 cases).The differences of age,gender,blood routine,liver function,D-dimer,creatinine,CK,CK-MB,cTnI and other laboratory test indicators in the two groups were compared.Univariate and multivariate Logistic regression methods were used to analyze the influencing factors of patient prognosis,and receiver operating characteristics(ROC)curve was used to analyze the predictive value of influencing factors to the occurrence of DEACMP.Results:The levels of CK,CK-MB and cTnI in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.001).The results showed that the area under the curve(AUC)of CK was 0.886,with a cutoff value of 375.000 U/L,and the sensitivity and specificity were 0.909 and 0.753,respectively.The AUC of CK-MB was 0.947,with a cutoff value of 11.500 μg/L,and the sensitivity and specificity were 1.000 and 0.825,respectively.The AUC of cTnI was 0.864,with a cutoff value of 0.420 μg/L,and the sensitivity and specificity were 0.864 and 0.733,respectively.Conclusions:Three biomarkers,CK,CK-MB and cTnI,have predictive value for DEACMP,which are helpful for early identification and early prevention of poor prognosis.
Keywords：Delayed encephalopathy after acute carbon monoxide poisoningCreatine kinaseCreatine kinase isoenzymeCardiac troponin IPrognosis
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 102-105 )