Research progress of type II alveolar epithelial cells in acute lung injury caused by sepsis
Chen Jianming
Zhang Min
Tao Zhangbin
Li Yan
Su Xiayi
Lu Zhongqiu
Abstract：Sepsis-associated acute lung injury(SALI)is a common complication of sepsis,characterized by a high incidence and poor prognosis.However,the underlying pathophysiological mechanisms of SALI remain incompletely understood.Further exploration of the mechanisms driving SALI may facilitate targeted therapeutic strategies and improve patient outcomes.This article reviews the pathophysiological mechanism of type Ⅱ alveolar epithelial cells(AEC Ⅱ)in SALI and the potential clinical significance of type Ⅱ alveolar epithelial cells in SALI diagnosis and treatment,as well as the key problems in the study of type Ⅱ alveolar epithelial cells in SALI and the possible strategies to overcome these problems.The in-depth investigation of molecular mechanisms and pathophysiological characteristics in AEC Ⅱ not only elucidates the underlying pathogenesis of SALI,but also provides a scientific foundation for developing targeted therapeutic strategies.
Keywords：Sepsis-associated induced acute lung injuryType Ⅱ alveolar epithelial cellsAlveolar-capillary barrierPulmonary surfactantInflammatory response
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 76-82 )