Research Progress on the Effect of Traditional Chinese Medicine on Diabetic Wound Healing through the PI3K/Akt Signaling Pathway
Abstract：Diabetic wounds refer to wounds caused by surgical incisions or trauma in diabetic patients. They are prone to infection, delayed healing, and even lead to various complications, causing great harm to patients' survival and quality of life. In diabetic wounds, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway plays an important role in reducing inflammation, alleviating oxidative stress, and regulating autophagy related to diabetic mechanisms. Some effective components and compound preparations of traditional Chinese medicine with good therapeutic effects on diabetic wounds also promote wound healing by regulating the PI3K/Akt signaling pathway. This article takes the regulation of the PI3K/Akt signaling pathway by TCM extracts and active components, as well as TCM compound prescriptions, as the starting point, and reviews the mechanisms by which TCM promotes diabetic wound healing through the regulation of the PI3K/Akt signaling pathway.
Keywords：DiabetesChronic WoundWound HealingPI3K/Akt Signaling PathwayTraditional Chinese MedicineOxidative StressAutophagyFerroptosis
Publication Date：2025-03-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 64-68,封3 )