Clinical study on Jiedu Shengji ointment(解毒生肌膏)regulating NLRP3 inflammatory bodies to alleviate inflammatory reaction of diabetes foot ulcer with toxin accumulation and canker syndrome
Zeng Anxing
Huang Xinling
Zhou Zhongzhi
Abstract：Objective:To explore the clinical efficacy of Jiedu Shengji ointment(解毒生肌膏)in regulating nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammatory body to reduce inflammatory reaction of foot ulcer in diabetes patients with toxin accumulation and ulceration syndrome.Methods:Forty-eight patients with diabetes foot ulcer syndrome of accumulated toxin and rotting were selected and randomly divided into the treatment group and the control group,with 24 patients in each group.Finally,3 cases were eliminated from each group.Both groups were given basic treatment.On this basis,the treatment group was given Jiedu Shengji ointment,and the control group was given sulfadiazine silver cream.The dressing was changed once a day and the course of treatment was 14 days.The changes in various expression such as Bates-Jensen wound assessment tool(BWAT)wound quantification score,exudate volume,clinical efficacy,positive rate of bacteria,NLRP3 inflammasome,interleukin-1β(IL-1β),and IL-18 were compared between the two groups on the 14th day of treatment.Hematoxylin-eosin(HE)staining was used to observe the histopathological changes of the wound surface.And the occurrence of adverse reactions in the two groups was recorded.Results:The total effevtive rate was 90.5％in the treatment group and 61.9％in the control grouf(P＜0.05).The wound quantification score,exudate situation,positive rate of bacteria,advanced glycation end products(AGEs),NLRP3 inflammasome,IL-1 β,and IL-18 in the treatment group were significantly lower than those in the control group(P＞0.05).During the treatment,no serious adverse reactions occurred in both group.Conclusions:Jiedu Shengji ointment can reduce the accumulation of AGEs in diabetes foot ulcers,reduce the expression levels of NLRP3 inflammatory bodies,IL-1β,IL-18 and other inflammatory mediators,improve the excessive inflammatory response,and promote ulcer healing.
Keywords：Jiedu Shengji ointment(解毒生肌膏)Diabetes foot ulcerPoison accumulation and ulceration syndromeInflammationNucleotide-binding oligomerization clomcin-like rceeptor protein 3
Publication Date：2025-03-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1-7 )