Relationship between Tim-1 gene polymorphism and immunosuppressive or steroid resistance in children with primary nephrotic syndrome
Wei Guang
Wang Fen
Abstract：Objective:To explore the relationship between T-cell immunoglobulin domain mucin domain protein-1(Tim-1)gene polymorphism and immunosuppressive or steroid resistance in children with primary nephrotic syndrome(PNS).Methods:Eighty children with PNS admitted to the 7th People's Hospital of Zhengzhou from June 2020 to January 2021 were selected as the study group.All of them were treated with immunosuppressive agents or steroid pulse therapy.According to treatment response,they were divided into sensitive type(n=65)and drug-resistant type(n=15).Meanwhile,60 healthy individuals were selected as the control group.Tim-1 gene polymorphisms and the independent factors influencing immunosuppressive agent or steroid resistance were analyzed.Results:The genotype frequencies and allele frequencies at-1454G/A of Tim-1 gene promoter region in the two groups were significantly different(P<0.05).There was no significant difference in allele frequency(P>0.05),while the genotype frequencies and allele frequencies at 4 ins/del of Tim-1 gene exon region showed no significant differences between the two groups(P>0.05).There was a significant difference between sensitive and drug-resistant children in genotype frequency at-1454G/A of Tim-1 gene promoter region(P<0.05).There was no significant difference in allele frequency(P>0.05).There was no significant difference in the distribution frequency and allele frequency of Tim-1 exon 4 ins/del genotype between sensitive and drug-resistant children(P>0.05).Genotype GA at-1454G/A of Tim-1 gene promoter region was an independent risk factor for immunosuppressive agent or steroid resistance children with PNS(P<0.05).Conclusions:Gene polymorphism at-1454G/A of Tim-1 gene promoter region may be genetic susceptibility mark of PNS,and is closely related to immunosuppressive agent or steroid resistance in children with PNS.
Keywords：Primary nephrotic syndromeT cells immunoglobulin domain and mucin domain protein-1Gene polymorphismImmunosuppressive agentSteroidChildren
Publication Date：2023-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 84-87,105 )