Studies on distribution and drug resistance of pathogenic bacteria of neonatal septicemia

Zuo Feifei

doi:10.3969/j.issn.1672-8521.2017.03.007

Abstract：Objective: To investigate and analyze the distribution and drug resistance of pathogenic bacteria of neonatal septicemia for providing the basis for clinical treatment. Methods: One hundred and six children with neonatal septicemia admitted in Luoyang Maternal and Child Health Care Center from Mar. 2015 to Mar. 2017 were selected as the subjects of present study, the hemoculture and drug sensitivity test were performed, and the distribution and drug resistance of pathogenic bacteria were then analyzed. Results: One hundred and twelve strains of pathogenic bacteria were isolated from patients' hemoculture, including 48 strains (42.85％) of Gram-positive bacteria, 62 strains (55.36％) of Gram-negative bacteria and 2 strains of fungi (1.79％). The main Gram-positive bacteria were Staphylococcus epidermidis, Streptococcus agalactiae and Staphylococcus aureus. Staphylococcus sp. showed rather high resistance to penicillin, but sensitive to vancomycin, while Streptococcus agalactiae was rather sensitive to penicillin. The main Gram-negative bacteria were Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae; they were rather sensitive to beta lactamase inhibitors and carbapenems. The two strains of fungi were Candida albicans. Conclusions:For treatment of neonatal septicemia, vancomycin can be used to resist staphylococcus infection. Penicillin is preferred for resisting streptococcus agalactiae. Gram-negative bacteria infection can be treated with beta lactamase inhibitor and carbapenems antibiotics.