Investigation of the relationship between Mycoplasma pneumoniae and virus infection and acute peripheral facial paralysis in children

Shen Yanwen; Wang Hua

doi:10.3969/j.issn.1672-8521.2017.03.006

Abstract：Objective: To retrospectively analyze the antibodies detection of Mycoplasma pneumoniae and virus in children with acute peripheral facial paralysis, and explore the relationship between pathogen infection and the disease. Methods: The infection data were retrospectively analyzed of children with acute peripheral facial paralysis admitted in the Pediatric Neurology Department of Affiliated Shengjing Hospital of Chinese Medical University during 2011-2013. Detection of varicella-zoster viral antibodies was not performed due to lack of certain kits in the hospital. Mycoplasma pneumoniae antibody was detected in all of 106 patients, among them 76 cases also received 8 common respiratory virus series, Epstein-Barr virus and herpes simplex virus antibodies detection (in which 3 cases also received cytomegalovirus-DNA detection additionally), 8 cases received 8 common respiratory virus series, Epstein-Barr virus and TORCH antibodies series detection (in which 1 case received cytomegalovirus-DNA detection additionally), and 14 cases received 8 common respiratory virus series and Epstein-Barr virus antibodies assay (in which 1 case received cytomegalovirus-DNA detection and another 1 case received Rotavirus antigen detection additionally), 1 case received 8 common respiratory virus series and herpes simplex virus antibodies detection, 1 case received 8 common respiratory virus series, TORCH antibodies series and cytomegalovirus-DNA detection, 3 cases received 8 common respiratory virus antibodies series detection (in which 1 case received Rotavirus antigen detection additionally), 3 cases received Mycoplasma pneumoniae antibody detection only. Results: Among the 106 cases with acute peripheral facial paralysis, 72 (67.92％) showed positive antibody of at least one pathogen. Among the 72 cases, 43 (40.57％) showed positive antibody of just on pathogen, and 29 (27.36％) showed positive antibodies of at least 2 pathogens. The serum etiologic assay showed negative in 34 cases (32.08％). There were 45 cases who showed positive Mycoplasma pneumonia IgM antibody or/and a total antibody titer above 1:320, among which 22 cases were suspected to be combined with the infection of EB virus, cytomegalovirus, herpes simplex virus and mumps virus, etc. Conclusion: There is a higher positive rate of Mycoplasma pneumoniae in children with acute peripheral facial paralysis in northeast China, which may be one of the most common pathogens inducing acute peripheral facial paralysis.