Changes and clinical significance of the contents of serum interleukin-23 and interleukin-15 in patients with Henoch-Schoenlein purpura
Liu Hongjun
Abstract：Objective:To investigate the expression and the clinical significance of interleukin-23 (IL-23) and interleukin-15 (IL-15) in serum of patients with Henoch-Schoenlein purpura (HSP).Methods:From Mar.2014 to Dec.2016,41 patients with HSP admitted in Puyang Hospital of Traditional Chinese Medicine (observation group) and 37 healthy subjects (control group) were involved in present study.Fasting venous bloods were sampled from the both groups after admission to detect serum IL-23 and IL-15 levels.Two weeks after treatment,patients in HSP group were divided into 2 groups according to the clinical efficacy as effective group (n=29) and ineffective group (n=12),the blood samples were then taken again for detection and comparison of serum IL-23 and IL-15 levels.Results:The levels of serum IL-23 and IL-15 were significantly higher in observation group than in control group with statistical significance (P＜0.05).Two weeks after treatment,the levels of serum IL-23 and IL-15 were significantly lower in effective group than in ineffective group with statistical significance (P＜0.05).Conclusion:IL-23 and IL-15 may take part in the pathogenesis of HSP,and detection of serum IL-23 and IL-15 levels may be in favour of evaluating the therapeutic effect of HSP.
Keywords：Henoch-Schoenlein purpuraInflammatory cytokineInterleukin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 110-112 )