Changes of cellular immune function and cytokines secreted by T lymphocyte after chemotherapy in patients with advanced lung cancer
Cao Zhe
He Ling
Zhou Jian
Zhang Yong
Mei Qi
Abstract：Objective:To investigate the changes of cellular immune function and cytokines secreted by T lymphocyte after chemotherapy in patients with advanced lung cancer.Methods:Flow cytometry was performed to detect the proportions of CD4+T and CD8+T lymphocytes in peripheral blood mononuclear cells (PBMCs) as well as the level of cytokines secreted by CD4+T cells.Results:The proportion of CD4+T in PBMCs and the ratio of CD4+T/CD8+T were lower in patients with advanced lung cancer than those of the control group (P＜0.001) before chemotherapy,and increased after chemotherapy (P＜0.01 or P＜0.001).The proportion of CD8+T in PBMCs was higher in patients with advanced lung cancer than those of the health controls (P＜0.001) before chemotherapy,then it decreased after chemotherapy (P＜0.05).However,no obvious changes were found in the levels of cytokines secreted by Thl (such as IFN-γ,TNF-α and IL-2) or Th2 lymphocyte (IL-4,IL-6 and IL-10) in patients.Conclusions:Chemotherapy may increase the proportion of CD4+T lymphocytes in PBMCs in patients with advanced lung cancer,but shows little effect on the changes of cytokines secreted by Th 1 or Th2.
Keywords：Lung cancerChemotherapyImmunocyteCytokines
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 90-93 )